Spontaneous rhythmic activity is a hallmark feature of the developing retina, where propagating retinal waves instruct axonal targeting and synapse formation.Retinal waves cease around the time of eye-opening; however, the fate of the underlying synaptic circuitry is unknown.Whether retinal waves are unique to the developing retina or if they can L
A vast, two-volume list of all the towns and villages of the Kingdom of Poland was published in 1827, with the number of houses and residents, and the type of ownership specified in it.It was the only official publication issued by the then central statistical body of the state – The Statistical Office of the dress Government Commission for the I
Abstract Background The formation of the bicoid (bcd) mRNA gradient is a crucial step for Bcd protein gradient formation in Drosophila.In the past, a microtubule (MT)-based cortical network had been shown to be indispensable for bcd mRNA transport to the posterior.Results We report the identification of a MT-binding protein CLASP/Chb as the first c
The tumor suppressor kinases LATS1 and LATS2 (LATS1/2) regulate not only organ size through the Hippo signaling pathway, but also cell-cycle checkpoints and apoptosis via other signaling cascades.We previously reported that LATS1/2 localize to the mitotic apparatus, where they are involved in the phosphorylation and activation of the mitotic kinase
The paper analyzes the concept and indicator of vertical fiscal imbalance (VFI) and its capability in assessing the creditworthiness (debt sustainability) of Russian regions.It is found that VFI does not replace other indicators of debt and broader fiscal sustainability, but complements them by providing diagnostics of the balance of incoming and o